[ubuntu] Wine & Hard Drive Space

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http://ubuntuforums.org – Hey all, I am brand new to Ubuntu. I have had it for about a week. I love it and all. I am using wine to run a windows program. Ubuntu 11.10 is installed on my OS hard drive which is roughly 50GB. I want to keep as much stuff off that hard drive as possible. Is there a way to install a program through wine onto my secondary hard drive that is 500GB? If so how do I do that. Again I am new to Ubuntu, and but am fairly tech savy. I have no programming background, just fyi. Thanks for the help. (Hardware)