Tomcat connection errors with too many users

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http://serverfault.com – I am load testing an app that runs on Tomcat (6.0.33). As I increase the number of users I start to get connection problems. Here is what jMeter returns. I am pretty new to Tomcat, can anyone give any advice on where to even start looking? org.apache.http.conn.HttpHostConnectException: Connection to https://example.domain.edu refused at org.apache.http.impl.conn.DefaultClientConnectionOperator.openConnection(DefaultClientConnectionOperator.java:190) at org.apache.http.impl.conn.ManagedClientConnectionImpl.open(ManagedClientConnectionImpl.java:294) at org.apache.http.impl.client.De (HowTos)