Stumped No Route to host

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http://forums.fedoraforum.org – I have fedora 15 and use sendmail. All has been fine until a week ago and all of a sudden I am getting No route to host errors. This server has been working for almost 2 years. I have tried to telnet to port 25 that works but telnet to local host I get a time out. The host file hasn't changed and is correct, I disabled the firewall no change. Any Ideas?? (HowTos)