SQLSTATE[HY000]: General error: 2006 MySQL server has gone away

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http://serverfault.com – Server details: RAM: 16GB HDD: 1000GB OS: Linux 2.6.32-220.7.1.el6.x86_64 Processor: 6 Core Please see the link below for my # top preview: I can often see the error mentioned in title in my plesk panel and my /etc/my.cnf configuration are as below: bind-address= local-infile=0 datadir=/var/lib/mysql socket=/var/lib/mysql/mysql.sock user=mysql max_connections=20000 max_user_connections=20000 key_buffer_size=512M join_buffer_size=4M read_buffer_size=4M read_rnd_buffer_size=512M sort_buffer_size=8M wait_timeout=300 interactive_timeout=300 connect_timeout=300 tmp_table_size=8M th (HowTos)