Reverse proxy with client certificate authentication

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http://serverfault.com – My company wants to expose BizTalk services to external trading partners using ISA/TMG and SSL client certificates to authenticate. We were told by a Microsoft engineer that this is not possible if the certificates do not authenticate against our AD. Is this true? We are considering using Symantec Managed PKI. https://www.symantec.com/verisign/managed-pki-service (HowTos)