Removing lines from a file that are in another file

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http://www.linuxquestions.org – I have a large text file containing over 180k lines and another text file containing about 1k. I would like to remove lines in the 180k-line file that exist in the 1k-line file. I thought there was a simple way to do this but I haven't come across it yet. Any advice? Thanks :) (HowTos)