Reason for packet loss and Unreachable?

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http://serverfault.com – For past days experienced in periods a very slow server and several crashes where the server becomes almost 100% unreachable - (Packet loss 70-90% from all location) and it is now network related as i have confirmed from the DC. A reboot fixes the problem usually temporary but the problem usually arises again within a few hours. So, may i know how to investigate it. (HowTos)