Pen drive lifetime issues when running OS from it

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http://askubuntu.com – I intend to install Ubuntu onto a 32GB pendrive. I've heard that the lifetime of a pendrive will reduce drastically due to the large number of read/writes due to running /tmp from pendrive. Does this issue really affect modern pendrives and how to use the RAM as tmpfs instead of having /tmp in the pendrive? (HowTos)