Outlook 2010 Security Settings and Hardening

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http://serverfault.com – We are looking at rolling out Outlook 2010 in the near future. What recommendations, guides, settings, tools, etc. would you recommend to secure and harden the installation and usage of Outlook 2010? What works and what does not work? Note: I am not looking for the pros and cons of using Outlook, just how to secure it and what settings should been toggled or implemented. Note 2: This would be for average users in a large enterprise setting for daily e-mail use with the possibility in the future of using personal digital certificates. Hardening it from what would be answered the same way (HowTos)