MS Server 2008 R2 backup solutions native vs non-native with virtual guests

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http://serverfault.com – basically I'm getting ready to install a MS Server 2008 R2 (Standard edition) onto a physical box (12 GB RAM AMD 6 core Phenom with + 2 TB storage) which will serve as a host for at least 1 and up to 3 virtual Linux server(s) at any one time. I'm comfortable on 2008 R2 but I'm not 100% confident in the backup solutions that I've been seeing in searches on various sites. Any backup solution will essentially be for cloning disk images as in full system state backups. So what I want is to know if anyone has had mid or long-term issues using the native Windows backup. I'd like to know if there (HowTos)