Mixing 4k/512 drives with ZFS (FreeNAS)

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http://unix.stackexchange.com – I have the following drives: Seagate Barracuda ST3200054AS WDC WD20EADS-00S2B0 Samsung HD204UI As far as I understand, the first are ordinary 512 drives while the last is 4096 (Advanced format). Together with a new 2TB drive, I want to create a 6TB RAIDz1 with ZFS in FreeNAS. The new drive must most likely be also Advanced format because the old 512 are becoming rare/expensive. So I will effectively have two 512-byte-block and two 4096-byte-block drives. What special things must I take care in order to not decrease performance? When I chose "Force 4096 bytes sector size" in the volume ma (HowTos)