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IPC overhead in a (nginx -> uwsgi -> wsgi application) architecture?

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http://serverfault.com – Recently I'm setting up some Python website and it seems the architecture nginx -> uwsgi -> wsgi application is an obvious choice in Python world these days. (Actually I'm migrating a MoinMoin site backed by Apache + mod_wsgi to a newer VM running nginx so I took time to look at nginx-backed deployment possibilities.) I've read a lot about why there needs to be such indirection layers, and I'm fully aware that the individual techniques involved - nginx, uwsgi and wsgi - are all modern, featureful of very high performance, and all mature as of today. But since in such an architecture the (HowTos)