Good backup strategy for heterogeneous data consisting of images/databases/office files/svn repositories/

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http://serverfault.com – I'm looking for a simple on-site (i.e. not online) backup solution for our small company. Right now we have approximately 4TB of data in total, maybe adding ~500GB per year. The amount of data changing per day is much less tough - I guess much less than 1GB on average. All data is only accessed from the intranet and most machines are running Windows and some are running under MacOS if it matters. The data in detail: (a) Large parts of the data are images/videos/documentation(pdf) and alike, I would guess 2.5TB. (b) Frequently accessed are our CAD-data files, but they only take up 10-20GB. (HowTos)