General Custom Launcher Question

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http://androidforums.com – Say I go with a custom launcher, what exactly do I lose out on when doing it? Do I lose multi-window? What part of the s-pen functionality disappears? Trying to make an informed decision before I go downloading things... My friend has been spending a lot of tonight trying to talk me into trying out Apex or Nova, but I'm hesitant since I bought this particular phone for the s-pen. I don't use multi-window very often, but mainly because until yesterday I couldn't use my apps on it. So now that I can do that, I'm not sure I'd like to part with that either. Anyhow, thanks in advance f (General)