Fedora 16 KDE: Are the packages the same format?

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http://askubuntu.com – I'm thinking of installing Fedora 16 in the KDE interface just to try it out. What's the difference between that one and Fedora 16 in GNOME 3... If I wanted to install Skype for instance, would I be able to downloaded the same .rpm installer and use it? Or does the fact that it's KDE change the way you install programs? Sorry, I'm relatively new to anything but Ubuntu. (HowTos)