Executing a software on another network interface?

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http://serverfault.com – I have created 3 virtual interface on a Linux system, using different IP. I have a software doing requests to a server but it use the default interface, eth0. Is it possible to execute a software using another ip/interface temporarily ? Like eth0:1 ? Something like : USE_INTERFACE=eth0:1 node test.js Thanks (HowTos)