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Edit first line of a text file

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linux-howto

http://www.unix.com – Hi friends, Issue1: I have a text file with the first line like this Code: #chrom        start        end        Readcount_A        Normalized_Readcount_A        ReadcountB        Normalized_Readcount_B        Fc_A_vs_B        pvalue_A_vs_B        FDR_A_vs_B        Fc_B_vs_A        pvalue_B_vs_A        FDR_B_vs_A        < (HowTos)