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Change a character based on its position number

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linux-howto

http://www.unix.com – Hi I have a text file that I want to change some of the characters based on their position. My file contain multiple lines and characters should be counted continuously line by line. For example, I want to convert the 150th T to C. What can I do? Here is a portion of my file: Code: GATCACAGGTCTATCACCCTATTAACCACTCACGGGAGCTCTCCATGCAT TTGGTATTTTCGTCTGGGGGGTGTGCACGCGATAGCATTGCGAGACGCTG GAGCCGGAGCACCCTATGTCGCAGTATCTGTCTTTGATTCCTGCCTCATT CTATTATTTATCGCACCTACGTTCAATATTACAGGCGAACATACCTACTA AAGTGTGTTAATTAATTAATGCTTGTAGGACATAATAATAACAATTGAAT GTCTGCACAGCCGCTTTCCACACAGACATCATAACAAAAAATTTCCACCA AACCC (HowTos)