Caveats when upgrading from RHEL 5.4 to RHEL 6.3 on hundreds of production servers

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http://serverfault.com – I am about to upgrade the RHEL version from RHEL 5.4 to RHEL 6.3 in a few hundreds of production servers. The upgrade will be tested on a staging environment on virtual machines before production deployment. Are there any backward-compatibility issues with RHEL upgrades? (HowTos)