Automate checking user submitted files

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http://unix.stackexchange.com – Since last few days, I'm facing some problem. It's about response to 100 users. Situation goes like this. On one end there are 100 user, each user has unique ID. User is supposed to submit one file to server/mail. At receivers end, someone has to check whether submitted file is in particular format or not. I want to automate to this process, starting from server/mailbox where some script should download submitted file, check it and store result in some output file. Can we setup some server on unix machine?can we use some mailbox to which people can send files in the form of an email? Please s (HowTos)